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This book examines the behavior of high-tech startups and important aspects of innovation ecosystems in Brazil. It discusses how the local business environment boosts startups and high-tech entrepreneurship, leading to the most successful implementation of technology parks and incubation movements in Latin America. In the first part, the chapters explore the experience of Brazilian high-tech startups with regard to innovation, funding, background of the entrepreneur and their efforts entering international markets. The second part is dedicated to innovation ecosystems and explains the role of business incubators, acceleration programs, and university entrepreneurship in the country.