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Textbook of Medicinal Chemistry – II is an essential resource for students and professionals in the field of medicinal chemistry and pharmacology. The book offers a comprehensive exploration of key therapeutic agents, their chemical properties, mechanisms of action, and clinical applications. The content is meticulously organized into twelve chapters, each focusing on a specific class of drugs. It begins with antihistaminic agents, detailing histamine receptors, H1 and H2 antagonists, and gastric proton pump inhibitors. The chapter on anti-neoplastic agents explains the classification and mechanisms of anticancer drugs, including alkylating agents, antimetabolites, antibiotics, and plant products. The text thoroughly examines anti-anginal drugs, including vasodilators and calcium channel blockers, and provides an extensive review of diuretics, categorized into carbonic anhydrase inhibitors, thiazides, loop diuretics, and more. It also covers anti-hypertensive agents, with discussions on ACE inhibitors, beta blockers, and vasodilators. Further chapters delve into anti-arrhythmic drugs and anti-hyperlipidemic agents, highlighting their classifications and pharmacological profiles. The book explores coagulants and anticoagulants, discussing key drugs like warfarin and clopidogrel, as well as treatments for congestive heart failure. A dedicated section addresses drugs acting on the endocrine system, including sex hormones, corticosteroids, and thyroid medications. The book also discusses antidiabetic agents, covering insulin, sulfonylureas, biguanides, and newer drug classes. Finally, it examines local anesthetics, with an in-depth look at their structure-activity relationships and chemical derivatives. With detailed explanations and a structured approach, this textbook serves as an invaluable guide for mastering the concepts of medicinal chemistry.