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The Textbook of Novel Drug Delivery Systems is a comprehensive academic resource designed to provide a thorough understanding of advanced drug delivery mechanisms. It serves as an essential guide for pharmacy students, researchers, and professionals interested in developing more effective and targeted therapies. The book begins with an in-depth exploration of controlled drug delivery systems, introducing key terminology and foundational principles such as diffusion, dissolution, and ion exchange mechanisms. It covers physicochemical and biological properties of drugs critical to sustained release formulations, followed by a dedicated chapter on polymers, discussing their classification, properties, and application in drug design. The topic of microencapsulation is thoroughly addressed, with explanations of methods, advantages, and pharmaceutical applications of microspheres and microparticles. The book also delves into mucosal drug delivery systems, emphasizing bioadhesion principles and the formulation of buccal drug delivery platforms. It progresses into implantable drug delivery systems, detailing the use of implants and osmotic pumps for long-term therapeutic effects. The section on transdermal drug delivery outlines the structure of the skin, permeation enhancers, and formulation strategies for achieving systemic drug absorption. Gastroretentive systems are explained with emphasis on floating, high-density, and gastroadhesive techniques to increase gastric retention time. Readers are introduced to nasopulmonary delivery, with practical formulation details on dry powder inhalers, metered-dose inhalers, nasal sprays, and nebulizers. Targeted drug delivery concepts are thoroughly presented, including advanced carriers like liposomes, niosomes, nanoparticles, and monoclonal antibodies. The book also includes critical insights into ocular drug delivery, focusing on overcoming intraocular barriers using formulations and devices like ocuserts. Lastly, intrauterine drug delivery systems are examined, detailing IUD development, advantages, and limitations.