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This Textbook of Pharmaceutical Organic Chemistry-III is a comprehensive resource designed for students and professionals in the field of pharmaceutical sciences. It covers the fundamental principles of stereochemistry, including optical, geometrical, and conformational isomerism, which are crucial in drug design and medicinal chemistry. The book provides an in-depth study of chirality, racemic modifications, and resolution techniques, ensuring a strong conceptual foundation in stereochemistry. A major focus is given to heterocyclic chemistry, detailing the synthesis, reactivity, and medicinal applications of important heterocyclic compounds such as pyrrole, furan, thiophene, pyrazole, imidazole, oxazole, thiazole, pyridine, quinoline, acridine, indole, pyrimidine, purine, and azepines. Their relevance in pharmaceutical applications is extensively discussed. Additionally, the book explores stereospecific and stereoselective reactions, crucial in pharmaceutical synthesis, and emphasizes their role in the development of bioactive molecules. It also delves into important organic reactions of synthetic significance, such as metal hydride reductions, Clemmensen reduction, Birch reduction, Wolff-Kishner reduction, Oppenauer oxidation, Dakin reaction, and various rearrangements. With a structured and student-friendly approach, this book serves as an essential guide for understanding reaction mechanisms, synthesis strategies, and the chemical behavior of pharmaceutical compounds. It is a valuable resource for pharmacy students, researchers, and professionals involved in organic synthesis and drug development.