3 Review(s)

"Computer aided drug development is an evolutionary technology significantly used in pharmaceutical research and development. It is facilitated with the tools of computer aided drug designing like molecular modelling, molecular designs, simulations, optimization etc. These can contribute to accelerate the drug discovery and development of drugs. The computer technology has shown tremendous applications in various stages of drug synthesis routes and assisting in designing drug molecules. Computer-aided intelligent machines and principles of artificial intelligence is now-a-days widely applied in healthcare sector.Chapter one describes the history of computers, applications and statistical modelling in pharmaceutical research and development process. Basic theoretical discussions of the principles of Quality-by-Design in pharmaceutical industry their guidelines and overview of regulations and scientific examples.Chapter two explains the computational modelling techniques in drug disposition and various computational processes available for in silico pharmacokinetic assessment of drug molecule. Chapter three illustrates the concepts of optimization & technology to design the experiments, describes the role of computers in pharmaceutical formulation development and principles of ethics & protecting innovations of computing in pharmaceutical research.Chapter four highlights the principles employed in gastrointestinal absorption simulation taking into account all the relevant biopharmaceutical properties through dynamic models, computer simulations in PKPD and awareness of computers in clinical data collection, management and regulation of computer systems.Chapter five briefs about the Artificial Intelligence (AI) in drug discovery & drug screening its applications, robotics and computational fluid dynamics in pharmaceutical automation, and their current challenges & future directions.Chapter six focus on the applications of Artificial Intelligence in dentistry and emphasizes the impact of AI in the core disciplines of dentistry including Radiology, Orthodontics, Periodontics, Endodontics, Oral Surgery, Prosthodontics, Oral Pathology and Public health Dentistry."