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The attempt to structure and communicate new ways of composing and hearing music has led to musical applications of set theory, abstract algebra and number theory. Some composers have incorporated the golden ratio and Fibonacci numbers into their work. Though ancient Chinese, Indians, Egyptians and Mesopotamians are known to have studied the mathematical principles of sound, the Pythagoreans (in particular Philolaus and Archytas) of ancient Greece were the first researchers known to have investigated the expression of musical scales in terms of numerical ratios, particularly the ratios of small integers. Their central doctrine was that "all nature consists of harmony arising out of numbers". From the time of Plato, harmony was considered a fundamental branch of physics, now known as musical acoustics. Early Indian and Chinese theorists show similar approaches: all sought to show that the mathematical laws of harmonics and rhythms were fundamental not only to our understanding of the world but to human well-being. Confucius, like Pythagoras, regarded the small numbers 1,2,3,4 as the source of all perfection.