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Blazars, the most extreme active galactic nuclei with powerful relativistic jets extending out to kiloparsecs from their central engine, are among the most intriguing and consistently bright objects in the observable Universe. Understanding how they form and shine has been a cumbersome endeavor since their discovery in the 1960s, with several fundamental questions remaining open to this day. The 2020s mark the beginning of a new era of large-scale surveys, multimessenger astrophysics, high-energy polarization, and extreme angular resolution, setting the ideal stage to study astrophysical jets. IAU Symposium 375 was the first IAU symposium to take place in Nepal. It brought together experts from all aspects of the blazar community to facilitate the building of new collaborative efforts to take advantage of the wealth of incoming data that will help provide answers to long-standing questions. It also supported local efforts to promote astrophysics and astrophysical research in Nepal.