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This book constitutes the refereed proceedings of the 11th Annual Conference on Theory and Applications of Models of Computation, TAMC 2014, held in Chennai, India, in April 2014. The 27 revised full papers presented were carefully reviewed and selected from 112 submissions. The papers explore the algorithmic foundations, computational methods and computing devices to meet today's and tomorrow's challenges of complexity, scalability and sustainability, with wide-ranging impacts on everything from the design of biological systems to the understanding of economic markets and social networks.