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The global community is negatively impacted on a large-scale with tens of millions of people world-wide suffering from major depression. Economic growth is being stunted and lifestyles and lives crippled. Unfortunately, it is not clear what the myriads of causative factors are. Is it stress alone or stress caused by medical or psychological disorders or unknown combinations of these and other factors? This book tackles these issues head on by presenting the latest research findings in this pandemic.