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Science is based on the measurement of physical quantities and reconciling them with theoretical formulations. Some of the major unsolved problems in physics are theoretical. Existing theories seem incapable of explaining certain observed phenomena or experimental results. In many cases, there are difficulties in creating experiments to test proposed theories, such as String Theory, or investigate some phenomena in greater detail, like the disappearance of electrons between atoms’ shells. The required technology to measure activities near the Planck units of measurements are not yet available. This book describes the biggest unsolved riddles in physics including 20 various topics.