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Amend soil with aged manure or compost before planting.Growing vines on raised rows, known as hills, ensures good drainage and the heat from sun remains locked in for a longer time.Muskmelon vines are really tender and should not be transplanted until frost has completely vanished.Plant seeds one inch deep, 18 inches apart, in mounds about 3 feet apart.If you have limited space, vines can be backed by a trellis.