3 Review(s)

Still recognized as the definitive text on practical topics related to organic chemistry, this text is relied upon by undergraduates, postgraduate students, and professional organic chemists. Topics covered include the structural and theoretical principles required when designing a synthesis; the disconnection or synthon approach; the principles of retro-synthetic analysis applied to relevant alphabetic, aromatic, alicyclic and heterocyclic compounds; and developments in reaction techniques. Salient Features An introductory chapter on the structural and theoretical principles required when designing a synthesis. The disconnection on synthon approach now integrated into the text , and the principles of retrosynthetic analysis applied to relevant aliphatic, aromatic, alicyclic and heterocyclic compounds. Synthesis methodology is expanded to cover a range of new reagents, including oxidants and reductants; reagents for asymmetric synthesis; and those derived from lithium, boron, silicon, phosphorous and suphur. Recent developments in reaction techniques which include: handling of air-sensitive and moisture-sensitive compounds; new chromatographic procedures; phase transfer catalysis; and solid support reagents. Over 100 new experiments selected from the literature to illustrate new reagents and techniques, and the operation of protection, selectivity and control in synthesis. A more detailed treatment of carbon-13 n.m.r. spectroscopy, and the interpretation of spectroscopic data for many of synthesized compounds.