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WILD BUCK Glutamine is the most abundant amino acid in the blood and in muscle cells. It is classified as a conditionally essential amino acid, which means that the body is normally capable of manufacturing enough to meet its metabolic needs. But under certain conditions, additional glutamine may be required. For example, during intense exercise, glutamine levels deplete, which means that more glutamine will be required. Since the body is in need and cannot produce enough (even though it can be made by the body), it is necessary to supplement with glutamine to help meet the body's demands.