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For over half a century, this book has served the discipline of medicinal chemistry for both graduate and undergraduate pharmacy and chemistry students as well as practicing pharmacists. Fully updated for the Twelfth Edition, coverage begins with the fundamental principles of chemistry, biochemistry, and biology that underlie the discipline of medicinal chemistry. These principles are then applied to understanding the properties, mode of action, therapeutic applications, and limitations of various pharmaceutical agents. The subject matter is organized by pharmaceutical and therapeutic classes, providing a bridge between the basic sciences and clinical practice. The text contains many tables for quick reference to names, formulations, dosages, and applications. This edition includes chapter review questions. A companion website provides answers to the review questions for students and an image bank for faculty. Salient Features NEW! Chapter Review Questions to reinforce concepts learned in each chapter NEW! Chapter Overview introduces students to the topic of each chapter NEW! Highlight color added to heighten book's visual appeal Logically organized by pharmaceutical and therapeutic class for quick, easy reference Plenty of tables for quick reference to names, formulations, dosages, and applications Table of Contents     1. Introduction     2. Drug Design Strategies     3. Metabolic Changes of Drugs and Related Organic Compounds     4. Biotechnology and Drug Discovery     5. Immunobiologicals     6. Anti-infective     7. Antimalarials     8. Antibacterial Antibiotics     9. Antiviral Agents     10. Antineoplastic Agents     11. Agents for Diagnostic Imaging     12. Central Nervous System Depressant     13. Central Dopaminergic Signaling Agents     14. Anticonvulsants     15. Central Nervous System Stimulants     16. Adrenergic Agents     17. Cholinergic Drugs     18. Renal Acting Agents     19. Cardiovascular Agents     20. Hormone Related Disorders: Nonsteroidal Therapies     21. Agents Treating Bone Disorders     22. Anesthetics     23. Histamine and Antihistaminic Agents     24. Analgesics     25. Steroids and Therapeutically Related Compounds     26. Prostaglandins, Leukotrienes, and Other Eicosanoids     27. Proteins, Enzymes and Peptide Hormones     28. Vitamins and Related Compounds     29. An Introduction to the Medicinal Chemistry of Herbs     Index