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This reference book for system engineers, architects, and managers focuses on how to design, analyze, and deploy Web service-based workflows for both business and scientific applications in a broad domain of healthcare and biomedicine. It discusses recent research and development results, as well as applications including healthcare and biomedical applications such as personalized healthcare processing, DNA sequence data processing, and electrocardiogram wave analysis. It also presents key methods such as Petri nets and social network analysis to advance the theory and applications of workflow design and Web service composition.