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In the field of Food Science and Nutrition, understanding the intricate relationship between diet, health, and disease is paramount. This manual provides a structured approach to mastering the application of nutritional principles in clinical settings. It is tailored to address the specific needs of students who are not only seeking academic excellence but also striving to make a tangible impact in the field of therapeutic nutrition. In the pages that follow, students will find a series of hands-on exercises, case studies, and practical exercises that enhance the skills of the students in assessing nutritional needs and planning dietary interventions. Each section has been meticulously developed to enhance the student’s ability to assess, plan, and implement nutritional interventions tailored to diverse patient needs. The author’s goal is to foster a learning environment where theory and practice seamlessly intersect. By engaging with the material, students will gain valuable experience in conducting nutritional assessments and developing therapeutic diet plans. This hands-on approach is crucial for developing the critical thinking and problem-solving skills required for success in clinical settings.