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This comprehensive manual serves as a source of basic and clinical information for the physician regarding viruses and viral diseases and as a reference source for laboratorians to aid in the diagnosis of virus infection by providing detailed information on individual techniques. Section one of the manual describes laboratory procedures to detect viruses, including quality control in the laboratory and specimen handling. Individual chapters provide information or a detailed protocol on how to set up and test samples for viral diagnosis. The second section focuses on the viral agents and the third is a reference of the various federal, state, and local laboratories that diagnose virus infections.