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The special issue on "Computational Analysis of Heat Transfer in Fluids and Solids" of the journal "Defect and Diffusion Forum" addresses various novel nonlinear models and computational techniques important for tackling the heat transfer phenomenon in fluids and solids. Numerical results are discussed quantitatively to illustrate the salient features of practical engineering and industrial applications. Topics covered by excellent research papers in this issue include: extended surfaces fins, reactive flow problem, Newtonian and non-Newtonian flow, nanofluids dynamics, boundary layer flow, natural convection, hydrodynamic stability, biomechanics, plasma physics, physics of dusty plasma, forced convection, mixed convection, magnetohydrodynamics, thermal radiation, porous media flow and irreversibility analysis. We anticipate that our special issue will stimulate and help a wide audience of researchers, engineers and educators from various fields of human activity.