3 Review(s)

Through use of this text, the reader is educated about the death ligands, death receptor pathways and their alterations in human cancer. The reader will learn about novel emerging signal transduction cascades and their complex regulation and cross-talk with other intracellular signaling pathways that impact on cell survival. Upon reviewing the text, the reader is exposed to current thinking about the role of death ligands and death receptors in-vivo, with respect to tumor suppression and important aspects of the immune response. In closing, the editors explain strategies for the use of death receptor pathways to develop diagnostic and therapeutic strategies for cancer.