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These proceedings present the results of the Eleventh International Conference on Dependability and Complex Systems DepCoS-RELCOMEX which took place in a picturesque Brunow Palace in Poland from 27th June to 1st July, 2016. DepCoS-RELCOMEX is a series of international conferences organized annually by Department of Computer Engineering of Wroclaw University of Science and Technology since 2006. The roots of the series go as far back as to the seventies of the previous century - the first RELCOMEX conference took place in 1977 - and now its main aim is to promote a multi-disciplinary approach to dependability problems in theory and engineering practice of complex systems. Complex systems, nowadays most often computer-based and distributed, are built upon a variety of technical, information, software and human resources. The challenges in their design, analysis and maintenance not only originate from the involved technical and organizational structures but alsofrom the complexity of the information processes that must be efficiently executed in a diverse, often hostile operational environment. Traditional methods of reliability evaluation focused only on technical resources are usually insufficient in this context and more innovative, multidisciplinary methods of dependability analysis must be applied. The diversity of the topics which need to be considered is well illustrated by the selection of the submissions in these proceedings with their subjects ranging from mathematical models and design methodologies through software engineering and data security issues up to practical problems in technical, e.g. transportation, systems.