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The purpose of the book "Genomic Computational Screening" is to uncover genetic changes linked to particular traits, diseases, or phenotypes by examining the junction of genomics, computational biology, and screening techniques. The book provides an introduction to the study of genomic data, encompassing epigenomic, DNA, and RNA sequencing. A summary of the software and tools used in bioinformatics for processing, analysing, and interpreting genetic data. Overview of genetic resources and databases, including dbSNP, EnSembl, and GenBank. Genome-wide association studies (GWAS): concepts and techniques for detecting genetic variants linked to complex traits and diseases, as well as other topics are covered. NGS technology applications include targeted sequencing for genetic screening, exome sequencing, and whole-genome sequencing. CRISPR-based screening techniques have been investigated for the purpose of identifying genetic targets and conducting functional genomics research. Variant calling and annotation, genomic medicine, pharmacogenomics, preventative genomics, and related topics are all areas of competence. In addition, new developments in genomic screening are being examined, including long-read sequencing, spatial transcriptomics, and single-cell genomics. Researchers, doctors, bioinformaticians, and students interested in using computational methods for genomic analysis and screening are the target audience for this book. It will give a thorough review of the fundamentals, procedures, uses, and difficulties of genomic screening with an emphasis on the computational and bioinformatics elements.