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This book is designed to help users quickly learn the primary features of the PSS application, a point-and-click interface for power analysis and sample size determination. The software provides computations for a variety of statistical analyses, including ttests; confidence intervals and equivalence tests for means; exact and approximate tests of proportions; multiple regression and correlation; one-way analysis of variance; linear models; and rank tests for comparing survival curves. The book describes the principal features of the application in detail. It also shows how to perform several standard analyses using the application, including two-sample ttest, analysis of variance, and two-sample survival rank tests. This title is intended for researchers, analysts, and statisticians who want to use PSS to perform power analysis and sample size determination.