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This book is a leadership guide to the effective implementation of the ISO 45001:2018 standard. It takes the high-level leadership and top management principles put forward in ISO 45001 and develops them into a comprehensive discourse on how, at the very top of any organization, large or small, leaders can drive the occupational health and safety (OH&S) agenda and ensure the effective implementation of the OH&S management systems. While the standard sets out expectations for top management, this book provides a clear explanation of the OH&S roles, responsibilities, and accountabilities between those who direct the organization and drive it towards achieving its strategic aims and those who lead the day-to-day operations. It puts forward a purposeful, easy-to-follow, and effective system for the implementation of ISO 45001 whilst also, and more importantly, maximizing the value proposition of such a global standard, regardless of industry. The book is written for top management teams of both non-executive and executive leadership, as well as senior advisors, in all organizations seeking to effectively implement OH&S policies and management systems. It can also be utilized to create training and learning materials to assist with implementation.