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In today's healthcare landscape, there is a pressing need for quantitative methodologies that include the patients' perspective in any treatment decision. Handbook of Generalized Pairwise Comparisons: Methods for Patient-Centric Analysis provides a comprehensive overview of an innovative and powerful statistical methodology that generalizes the traditional Wilcoxon-Mann-Whitney test by extending it to any number of outcomes of any type and including thresholds of clinical relevance into a single, multidimensional evaluation. The book covers the statistical foundations of generalized pairwise comparisons (GPC), applications in various disease areas, implications for regulatory approvals and benefit-risk analyses, and considerations for patient-centricity in clinical research. With contributions from leading experts in the field, this book stands as an essential resource for a more holistic and patient-centric assessment of treatment effects.