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Advances in imaging are occurring at a brisk pace, and imaging techniques have great potential to act as pre-symptomatic predictors of disease as well as to chart the course of a disease. Neuroimaging has greatly advanced the understanding of brain function and its relationship to the anatomical substrate. This volume brings together internationally renowned imaging scientists, those studying the aging brain, industry experts, and clinicians to jointly examine the most current methods and their application to brain physiology, behavior, and age-related diseases. These reports explore new technologies, data from recent neuroimaging initiatives, and translational research applications. Topics covered include (1) in vivo imaging of molecules, cells, and networks throughout the lifespan, (2) cutting edge imaging technologies and studies of the physiology of aging, (3) translational application of neuroimaging, and (4) emerging technologies in the private sector. This volume is the proceedings of a meeting that celebrated the 25th anniversary of the American Federation for Aging Research and its longstanding history of philanthropy in the area of aging research. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member