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Written in an accessible style, this second edition carefully explains fundamental principles, assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. The book opens with a broad overview of the subject with subsequent chapters examining topics in greater depth. The approach to medicinal chemistry is kept as simple as possible. Building on the success of the first edition, this edition has been completely revised and updated. Table of Contents Preface Acknowledgements. Abbreviations. An Introduction to Drugs, their Action and Discovery. Drug Structure and Solubility. Structure-activity and quantitative structures relationships. Computer aided drug design. Combinatorial Chemistry. Drugs from natural sources. Biological Membranes. Receptors and Messengers. Enzymes. Nucleic Acids. Pharmacokinetics. Drug metabolism. Complexes and chelating agents. Nitric oxide. An Introduction to drug and analogue synthesis. Drug Development and Production. Selective further reading. Answers to Questions. Index.