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The metabolism of modern agrochemicals in animals, plants, and the environment have been extensively studied and reported in the literature by scientists. The results of a considerable number of these studies have been presented at National ACS, AGRO Division meetings and eventually published in the Journal of Agricultural and Food Chemistry, the ACS Symposium Series, as well as other ACS journals and books. These studies support the current registrations and use ofpesticides in the United States and worldwide. The integration of metabolism and toxicological studies in assessing human risks to pesticides is best performed using predictive physiological pharmacokinetic/pharmacodynamic and QSAR models. Physiological, biochemical, and toxicological parameters arerequired for model development and is the subject of the chapters in this book. The book will update the scientific community in the development of the parameters required by pesticide PBPK/PD models and their application in model development, simulation, and risk assessment.