3 Review(s)

Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, Third Edition, is a primary textbook for a first course in pharmacology. It offers an integrated mechanism-based and systems-based approach, incorporating the cell biology, biochemistry, physiology, and pathophysiology of organ systems. The completely updated Third Edition features content reflecting current research findings, more than 400 full-color illustrations, Drug Summary Tables, and increased coverage of drug metabolism and the treatment of mycobacterial infections. Salient Features NEW! Incorporates full-color illustrations throughout (450 in total and 50 new) to highlight advances in physiologic, pathophysiologic and pharmacologic mechanism Comprehensive updated Drug Summary Tables (37 in total) which have been particularly popular readers. Introduction section in every chapter NEW! Features increased coverage of drug metabolism and the treatment of my co-bacterial infections, as well as updated cases and questions, all within the scope of clinical relevance Suggested Reading at the end of each chapter Represents & more than a drug dictionary: Golan first establishes a foundation for normal physiology, then covers pathophysiology, and concludes with pharmacology for a thorough understanding of the connections between each Features a signature pedagogical sequence for optimal learning and review: clinical scenario, questions, content, answers to questions, and conclusions Delivers content appropriate for students through a uniquely collaborative authorship consisting of medical students and faculty About the Author David E Golan MD, PhD, Professor of Biological Chemistry, Harvard Medical School, Boston, MA Armen H Tashjian Jr., MD, Professor Emeritus of Toxicology and Pharmacology, Harvard School of Public Health, Boston, MA April W Armstrong MD, Clinical Fellow, Department of Dermatology, Harvard Medical School, Boston, MA Table of Contents Section 1. Fundamental Principles of Pharmacology Chapter 1. Drug-Receptor Interactions Chapter 2. Pharmacodynamics Chapter 3. Pharmacokinetics Chapter 4. Drug Metabolism Chapter 5. Drug Toxicity Chapter 6 Pharmacogenomics Section 2. Principles of Neuropharmacology Section 2a. Fundamental Principles of Neuropharmacology Chapter 7. Principles of Cellular Excitability and Electrochemical Transmission Chapter 8. Principles of Nervous System Physiology and Pharmacology Section 2b. Principles of Autonomic and Peripheral Nervous System Pharmacology Chapter 9. Cholinergic Pharmacology Chapter 10. Adrenergic Pharmacology Chapter 11. Local Anesthetic Pharmacology Section 2c. Principles of Central Nervous System Pharmacology Chapter 12. Pharmacology of GABAergic and Glutamatergic Neurotransmission Chapter 13. Pharmacology of Dopaminergic Neurotransmission Chapter 14. Pharmacology of Serotonergic and Central Adrenergic Neurotransmission Chapter 15. Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous System Chapter 16. General Anesthetic Pharmacology Chapter 17. Pharmacology of Analgesia Chapter 18. Pharmacology of Chemical Dependence and Addiction Section 3. Principles of Cardiovascular Pharmacology Chapter 19. Pharmacology of Cholesterol and Lipoprotein Metabolism Chapter 20. Pharmacology of Volume Regulation Chapter 21. Pharmacology of Vascular Tone Chapter 22. Pharmacology of Hemostasis and Thrombosis Chapter 23. Pharmacology of Cardiac Rhythm Chapter 24. Pharmacology of Cardiac Contractility Chapter 25. Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, and Heart Failure Section 4. Principles of Endocrine Pharmacology Chapter 26. Pharmacology of the Hypothalamus and Pituitary Gland Chapter 27. Pharmacology of the Thyroid Gland Chapter 28. Pharmacology of the Adrenal Cortex Chapter 29. Pharmacology of Reproduction Chapter 30. Pharmacology of the Endocrine Pancreas Chapter 31. Pharmacology of Bone Mineral Homeostasis Section 5. Principles of Chemotherapy Chapter 32. Principles of Antimicrobial and Antineoplastic Pharmacology Chapter Chapter 33. Pharmacology of Bacterial Infections: DNA Replication, Transcription, and Translation Chapter 34. Pharmacology of Bacterial and Mycobacterial Infections: Cell Wall Synthesis Chapter 35. Pharmacology of Fungal Infections Chapter 36. Pharmacology of Parasitic Infections Chapter 37. Pharmacology of Viral Infections Chapter 38. Pharmacology of Cancer: Genome Synthesis, Stability, and Maintenance Chapter 39. Pharmacology of Cancer: Signal Transduction Chapter 40. Principles of Combination Chemotherapy Section 6. Principles of Inflammation and Immune Pharmacology Chapter 41. Principles of Inflammation and the Immune System Chapter 42. Pharmacology of Eicosanoids Chapter Chapter 43. Histamine Pharmacology Chapter 44. Pharmacology of Hematopoiesis and Immunomodulation Chapter 45. Pharmacology of Immunosuppression Chapter 46. Integrative Inflammation Pharmacology: Peptic Ulcer Disease Chapter Chapter 47. Integrative Inflammation Pharmacology: Asthma Chapter 48. Integrative Inflammation Pharmacology: Gout Section 7. Fundamentals of Drug Development and Regulation Chapter 49. Drug Discovery and Preclinical Development Chapter 50. Clinical Drug Evaluation and Regulatory Approval Chapter 51. Systematic Detection of Adverse Events in Marketed Drugs Section 8. Poisoning by Drugs and Environmental Toxins Chapter 52. Poisoning by Drugs and Environmental Toxins Section 9. Frontiers in Pharmacology Chapter 53. Protein-Based Therapies Chapter 54. Drug Delivery Modalities