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This text provides an account of process scale liquid chromatography. The basic theory is presented, guiding the reader through system design, simulation and modelling techniques, giving due consideration to economic aspects, as well as safety and regulatory factors. A survey of current techniques and media stresses their advantages and disadvantages in such a way as to facilitate their application to real-life problems. In view of the rapid rate of development in industrial chromatography, one chapter provides an assessment of future perspectives.