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This book summarizes recent progress regarding the theory, research, and practice of relapse prevention for depression. Part I discusses individual risk correlates and predictors for depression relapse and recurrence. Part II discusses the four treatments with the most empirical support for preventing depressive relapse: cognitive behavior therapy, interpersonal therapy, problem-solving therapy, and pharmacotherapy. Finally, Part III discusses relapse prevention in five key populations with an elevated risk for relapse: older adults, suicidal individuals, individuals with chronic medical illness, individuals with substance use disorders, and individuals with marital distress. The book concludes with an epilogue listing the editors' top ten guidelines for practitioners. With a heavy emphasis on implications for practice, this book will appeal to therapists and other health care workers, as well as depression researchers and graduate course instructors.